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Article

Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1.

The Journal of biological chemistry - 25 Jul 2008

Deng Hongbin, Yu Fei, Chen Jianqun, Zhao Yingming, Xiang Jialing, Lin Anning

Abstract excerpt

The mitogen-activated protein kinase JNK1 suppresses interleukin-3 withdrawal-induced cell death through phosphorylation of the BH3-only pro-apoptotic Bcl-2 family protein Bad at Thr-201. It is unknown whether JNK1 regulates glycolysis, an important metabolic process that is involved in cell survival, and if so, whether the regulation depends on Thr-201 phosphorylation of Bad. Here we report that phosphorylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18469002
DOI: 10.1074/jbc.M800024200
PMCID: PMC2475697

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