Article
14-3-3 inhibits Bad-induced cell death through interaction with serine-136.
Molecular pharmacology - 1 Dec 2001
Masters S C, Yang H, Datta S R, Greenberg M E, Fu H
Abstract excerpt
14-3-3 proteins are a family of multifunctional phosphoserine binding molecules that can serve as effectors of survival signaling. Understanding the molecular basis for the prosurvival effect of 14-3-3 may lead to the development of agents useful in the treatment of disorders involving dysregulated apoptosis. One target of 14-3-3 is the proapoptotic Bcl-2 family member Bad. Serine phosphorylation of Bad is...
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