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Article

Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034.

Oncogene - 24 Jun 2004

Fujii Katsunori, Goldman Erinn Hoag, Park Hae Ryoun, Zhang Lixin, Chen Jing, Fu Haian

Abstract excerpt

Apoptosis signal-regulating kinase 1 (ASK1) is a serine/threonine kinase that mediates cell stress signaling initiated by diverse stimuli, such as H(2)O(2) and TNF alpha. Owing to its critical role in promoting apoptosis, ASK1 activity is highly controlled in cells. Phosphorylation of ASK1 at Thr-845 has been correlated with its activation, while phosphorylation at Ser-967 negatively controls its death promoting...

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Source

Identifiers

PMID: 15094778
DOI: 10.1038/sj.onc.1207668

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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