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Article

The MDR phenotype is associated with the expression of COX-2 and iNOS in a human hepatocellular carcinoma cell line.

Hepatology (Baltimore, Md.) - 1 Apr 2002

Fantappiè Ornella, Masini Emanuela, Sardi Iacopo, Raimondi Laura, Bani Daniele, Solazzo Michela, Vannacci Alfredo, Mazzanti Roberto

Abstract excerpt

The presence of multiple drug resistance (MDR1) and angiogenic phenotypes negatively affect patients' prognosis with cancer even when treated with drugs that are not transported by the MDR1 gene product. It is possible to suggest a link between the MDR1 and angiogenic phenotypes. Because prostaglandins (PGs) and nitric oxide (NO) have been proposed to be involved in angiogenesis in vivo, the production of PGs and...

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PMID: 11915030
DOI: 10.1053/jhep.2002.32469

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EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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