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Article

Cyclooxygenase-2 inhibitors reverse chemoresistance phenotype in medullary thyroid carcinoma by a permeability glycoprotein-mediated mechanism.

The Journal of clinical endocrinology and metabolism - 1 Oct 2005

Zatelli Maria Chiara, Luchin Andrea, Piccin Daniela, Tagliati Federico, Bottoni Arianna, Vignali Cristina, Bondanelli Marta, degli Uberti Ettore C

Abstract excerpt

OBJECTIVE: Medullary thyroid carcinoma (MTC) is a highly chemoresistant malignant neoplasia deriving from parafollicular C cells. Chemotherapy failure has been ascribed, at least in part, to the overexpression by MTC of the multidrug resistance 1 (MDR1) gene, encoding a transmembrane glycoprotein [permeability glycoprotein (P-gp)] that antagonizes intracellular accumulation of cytotoxic agents. P-gp expression...

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Identifiers

PMID: 16091477
DOI: 10.1210/jc.2005-1362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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