Article

High expression of COX-2 and MDR1 implicate resistance development to imatinib therapy in chronic myeloid leukemia patients

2023-12-28

Abstract excerpt

Unresponsiveness of the chronic myeloid leukemia (CML) patients to frontline therapy of imatinib results in either dose escalation or change of drug leading to increased toxicity and financial burden. We have previously demonstrated cyclooxygenase-2 (COX-2)-dependent expression of efflux pumps via Wnt-signalling pathway as the underlying mechanism of imatinib resistance in vitro in K562 cells. The present study ai...

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Literature Corpus work: 810e6a9b-fac2-5db0-ae7f-46758fc19e43
DOI: 10.21203/rs.3.rs-3795259/v1

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