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Article

Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities.

Blood - 10 Feb 2011

Chiorazzi Nicholas, Ferrarini Manlio

Abstract excerpt

Several cell types have been suggested as giving rise to chronic lymphocytic leukemia (CLL), and these suggestions have reflected the sophistication of technology available at the time. Although there is no consensus as to the normal cellular counterpart(s) in the disease, an antigen-experienced B lymphocyte appears required based on surface membrane phenotypes and gene expression profiles. However, what is still...

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Share to B-Lymphocytes
Share to Cell Lineage
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Receptors, Antigen, B-Cell

Share to RNA, Neoplasm

Source

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Identifiers

PMID: 21148333
DOI: 10.1182/blood-2010-07-155663
PMCID: PMC3056635

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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