Article
In vitro and in vivo investigation of a novel monoclonal antibody to plasma cells (W5 mAb).
Xenotransplantation - 1 Jan 2004
Harper D, Gollackner B, Xu Y, Calderhead D, Ryan D, Li W, Cheng J, Wu C, Moran K, Latinne D, Bazin H, White-Scharf M E, Cooper D K C, Awwad M, Chang J
Abstract excerpt
Natural antibodies (Abs), predominantly anti-Gal alpha 1-3Gal (Gal) Abs, in non-human primates and human beings present a major hurdle to successful pig-to-primate xenotransplantation. Attempts to inhibit anti-Gal Ab production in naïve baboons using non-specific immunosuppressive or B cell-specific reagents have failed. A new rat monoclonal antibody (W5 mAb) has been generated, which binds to all B cells,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.