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What Have We Learned From In Vitro Studies About Pig-to-primate Organ Transplantation?

20 Dec 2022

Abstract excerpt

Natural preformed and de novo antibodies against pig antigens are a major cause of pig xenograft rejection in nonhuman primates (NHPs). In vivo studies in pig-to-NHP models are time consuming. In vitro assays, for example, antibody binding to pig cells, complement-dependent cytotoxicity assays, provide valuable information quickly and inexpensively. Using in vitro assays for several years, it has been documented...

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PMID: 36536507
DOI: 10.1097/tp.0000000000004458

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