Article
Novel strategies to target the humoral alloimmune response.
HLA - 1 Dec 2020
Suchanek Ondrej, Clatworthy Menna R
Abstract excerpt
Antibody-mediated rejection (ABMR) represents a major cause of late allograft loss in solid organ transplantation worldwide. This process is driven by donor-specific antibodies (DSA), which develop either de-novo or, in sensitized patients, are preformed at the time of transplantation. Effective targeting of ABMR has been hampered by a lack of robust randomized controlled trials (RCT), required for the regulatory...
Topics
- Alleles
- Graft Rejection
- HLA Antigens
- Histocompatibility
- Humans
- Isoantibodies
- Kidney Transplantation