Article
Sodium channel gene (SCN5A) mutations in 44 index patients with Brugada syndrome: different incidences in familial and sporadic disease.
Human mutation - 1 Jun 2003
Schulze-Bahr Eric, Eckardt Lars, Breithardt Günter, Seidl Karlheinz, Wichter Thomas, Wolpert Christian, Borggrefe Martin, Haverkamp Wilhelm
Abstract excerpt
The Brugada syndrome (BS) is a distinct form of idiopathic ventricular fibrillation and may cause sudden cardiac death in healthy young individuals. In the surface ECG, BS can be recognized by an atypical right bundle branch block and ST-segment elevation in the right precordial leads. Mutations in the cardiac sodium channel gene SCN5A are only known to cause BS. In a multi-center effort, we have collected...
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