Article
SCN1B gene variants in Brugada Syndrome: a study of 145 SCN5A-negative patients.
Scientific reports - 25 Sept 2014
Ricci Maria Teresa, Menegon Silvia, Vatrano Simona, Mandrile Giorgia, Cerrato Natascia, Carvalho Paula, De Marchi Mario, Gaita Fiorenzo, Giustetto Carla, Giachino Daniela Francesca
Abstract excerpt
Brugada syndrome is characterised by a typical ECG with ST segment elevation in the right precordial leads. Individuals with this condition are susceptible to ventricular arrhythmias and sudden cardiac death. The principal gene responsible for this syndrome is SCN5A, which encodes the α-subunit of the Nav1.5 voltage-gated sodium channel. Mutations involving other genes have been increasingly reported, but their...
Topics
- 3' Untranslated Regions
- Adolescent
- Adult
- Aged
- Brugada Syndrome
- Child
- Death, Sudden, Cardiac
- Exons
- Female
- Humans
- Male