Article
Genotype-Phenotype Correlation of SCN5A Genotype in Patients With Brugada Syndrome and Arrhythmic Events: Insights From the SABRUS in 392 Probands.
Circulation. Genomic and precision medicine - 1 Oct 2021
Milman Anat, Behr Elijah R, Gray Belinda, Johnson David C, Andorin Antoine, Hochstadt Aviram, Gourraud Jean-Baptiste, Maeda Shingo, Takahashi Yoshihide, Jm Juang Jimmy, Kim Sung-Hwan, Kamakura Tsukasa, Aiba Takeshi, Postema Pieter G, Mizusawa Yuka, Denjoy Isabelle, Giustetto Carla, Conte Giulio, Huang Zhengrong, Sarquella-Brugada Georgia, Mazzanti Andrea, Jespersen Camilla H, Arbelo Elena, Brugada Ramon, Calo Leonardo, Corrado Domenico, Casado-Arroyo Ruben, Allocca Giuseppe, Takagi Masahiko, Delise Pietro, Brugada Josep, Tfelt-Hansen Jacob, Priori Silvia G, Veltmann Christian, Yan Gan-Xin, Brugada Pedro, Gaita Fiorenzo, Leenhardt Antoine, Wilde Arthur A M, Kusano Kengo F, Nam Gi-Byoung, Hirao Kenzo, Probst Vincent, Belhassen Bernard
Abstract excerpt
BACKGROUND: Brugada syndrome (BrS) is associated with mutations in the cardiac sodium channel gene, SCN5A. However, genetic studies of patients with BrS with arrhythmic events have been limited. We sought to compare various clinical, ECG, and electrophysiological parameters according to SCN5A genotype in a large cohort of BrS probands with first arrhythmic event. METHODS: Survey on Arrhythmic Events in Brugada...
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