Article
A study of the SCN5A gene in a cohort of 76 patients with Brugada syndrome.
Clinical genetics - 1 Jun 2013
García-Molina E, Lacunza J, Ruiz-Espejo F, Sabater M, García-Alberola A, Gimeno J R, Cañizares F, García A, Martínez P, Valdés M, Tovar I
Abstract excerpt
We aim to study the SCN5A gene in a cohort of Brugada syndrome (BS) patients and evaluate the genotype-phenotype correlation. BS is caused by mutations in up to 10 different genes, SCN5A being the most frequently involved. Large genomic rearrangements in SCN5A have been associated with conduction disease, but its prevalence in BS is unknown. Seventy-six non-related patients with BS were studied. Clinical...
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