Article
A novel nonsense mutation in the SCN5A gene leads to Brugada syndrome and a silent gene mutation carrier state.
The Canadian journal of cardiology - 1 Sept 2005
Keller Dagmar I, Barrane Fatima-Zahara, Gouas Laetitia, Martin Johannie, Pilote Sylvie, Suarez Vivian, Osswald Stefan, Brink Marijke, Guicheney Pascale, Schwick Nicola, Chahine Mohamed
Abstract excerpt
BACKGROUND: Brugada syndrome (BS) is an electrical cardiac disorder with a right bundle branch block and ST segment elevation in leads V1 to V3 on surface electrocardiograms (ECGs), and is a syndrome that may lead to sudden cardiac death. PURPOSE: The aim of the present study was to screen for mu...
Topics
- Adolescent
- Adult
- Ajmaline
- Anti-Arrhythmia Agents
- Bundle-Branch Block
- Cell Line
- Codon, Nonsense
- Death, Sudden, Cardiac
- Electrocardiography
- Female
- Heart Diseases
- Humans
- Male
- Microscopy, Fluorescence
- Middle Aged