Brugada Syndrome: an exemplar for the genomic basis of sudden death.

Abstract excerpt

The inherited arrhythmia syndrome, Brugada Syndrome (BrS), is a leading cause of autopsy negative sudden death: the sudden arrhythmic death syndrome. Historically, BrS was believed to exhibit a Mendelian (autosomal dominant) mode of inheritance, caused by rare variants in SCN5A, the gene coding for the alpha subunit of the main cardiac sodium voltage channel. Challenges to this paradigm have arisen. For example,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Brugada Syndrome
• Share to Death, Sudden
• Share to Death, Sudden, Cardiac