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Article

SCN5A gene variants and arrhythmic risk in Brugada syndrome: An updated systematic review and meta-analysis.

Heart rhythm - 1 Oct 2024

Doundoulakis Ioannis, Pannone Luigi, Chiotis Sotirios, Della Rocca Domenico Giovanni, Sorgente Antonio, Tsioufis Panagiotis, Del Monte Alvise, Vetta Giampaolo, Piperis Christos, Overeinder Ingrid, Bala Gezim, Almorad Alexandre, Ströker Erwin, Sieira Juan, La Meir Mark, Brugada Pedro, Tsiachris Dimitrios, Sarkozy Andrea, Chierchia Gian Battista, de Asmundis Carlo

Abstract excerpt

BACKGROUND: A rare gene variant in SCN5A can be found in approximately 20%-25% of patients with Brugada syndrome (BrS). OBJECTIVE: The aim of this systematic review and meta-analysis was to evaluate the differences in clinical characteristics of BrS patients with and without SCN5A rare variants and the prognostic role of SCN5A for ventricular arrhythmias in BrS. METHODS: PubMed and Cochrane Central Register of...

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Source

Identifiers

PMID: 38614189
DOI: 10.1016/j.hrthm.2024.04.047

Genes

SCN5A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SCN5A gene variants and arrhythmic risk in Brugada syndrome: An updated systematic review and meta-analysis.PMID 38614189Read ↗

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