Article
Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth.
Developmental cell - 1 Feb 2004
Frei Christian, Edgar Bruce A
Abstract excerpt
The Drosophila cyclin-dependent protein kinase complex Cyclin D/Cdk4 induces cell growth (accumulation of mass) as well as proliferation (cell cycle progression). To understand how CycD/Cdk4 promotes growth, we performed a screen for modifiers of CycD/Cdk4-driven overgrowth in the eye. Loss-of-function mutations in Hif-1 prolyl hydroxylase (Hph), an enzyme involved in the cellular response to hypoxic stress,...
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