Article
Regulation of endothelial cell differentiation and transformation by H-Ras.
Experimental cell research - 15 Nov 2003
Rennel Emma, Cross Michael J, Klint Peter, Bai Xianhe, Arbiser Jack L, Gerwins Pär
Abstract excerpt
Angiogenesis is regulated by growth factors which activate tyrosine kinase receptors leading to the activation of a number of intracellular signaling pathways. The specific function of H-Ras during FGF-2 stimulated endothelial cell differentiation, defined as invasive growth and formation of branching networks in fibrin gels, was investigated by using conditionally immortalized endothelial cell lines induced to...
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