Article
Do chromosome abnormalities determine the type of acute leukemia that develops in CML?
Leukemia - 1 Jan 1990
Bernstein R, Gale R P
Abstract excerpt
Chronic myelogenous leukemia (CML) is characterized by two distinct phases--chronic and acute. Features of the chronic phase include proliferation and accumulation of mature myeloid cells and their progenitors; differentiation is seemingly intact. In contrast, the acute phase is characterized by impaired differentiation. Acute phase is heterogeneous--granulocytes, lymphocytes, megakaryocytes, and erythroid cells...
Topics
- Chromosome Aberrations
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid, Acute
- Multigene Family
- Phenotype
- Philadelphia Chromosome
- Trisomy
- Y Chromosome