Article
The in vitro metabolic inversion of R(-) to S(+) indoprofen.
European journal of drug metabolism and pharmacokinetics - 1 Jan 2000
Rossetti V, Lombard A, Buffa M, Miglietta A, Oliviero A, Gadoni E
Abstract excerpt
The paper reports a study on the metabolic inversion of indoprofen (2-[4-(2-isoindolinyl-1-one)-phenyl]-propionic acid) following incubation of the drug with liver microsomes from non-induced and phenobarbital-induced rats. The enantiomeric composition of the drug was determined after different incubation times of the racemate and the individual isomers. The S(+)/R(-) ratio was evaluated by densitometry following...
Topics
- Animals
- Chromatography, High Pressure Liquid
- Genetic Variation
- In Vitro Techniques
- Indoprofen
- Microsomes, Liver
- Phenobarbital
- Rats
- Rats, Wistar
- Stereoisomerism