Article
From the Viewpoint of Drug Metabolism Research.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Jan 2017
Nakajima Miki
Abstract excerpt
Since more than 70% of clinically used drugs are excreted from the body through metabolic processes, drug metabolism is a key determinant of pharmacokinetics, drug response and drug toxicity. Much progress has been made in understanding drug-drug interactions via the inhibition or induction of cytochrome P450s (P450, CYP), as well as the effects of genetic polymorphisms of P450s on pharmacokinetics, and this has...
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