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Article

Increased enzyme activity and beta-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2007

Gros Robert, Van Uum Stan, Hutchinson-Jaffe Adam, Ding Qingming, Pickering J Geoffrey, Hegele Robert A, Feldman Ross D

Abstract excerpt

OBJECTIVE: cAMP is a critical regulator of metabolic and cardiovascular function. However, the role of genetic variability in the regulation of cAMP-mediated effects is unclear. Therefore, we assessed the effect of the expression of a recently identified missense genetic variant of adenylyl cyclase isoform 6 (ADCY6 S674). METHODS AND RESULTS: In rat vascular smooth muscle cells, gene transfer of ADCY6 S674...

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Source

Identifiers

PMID: 17916776
DOI: 10.1161/ATVBAHA.107.145557

Genes

ADCY6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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