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Article

DHPLC is superior to SSCP in screening p53 mutations in esophageal cancer tissues.

International journal of cancer - 10 Mar 2005

Yamanoshita Osamu, Kubota Takeo, Hou Jun, Ping Yu-Min, Zhang Xiu-Lan, Li Xiang-Ping, Li Shao-Sen, Li Xiao-Xian, Zhu De-Chen, Fukushima Yoshimitsu, Nakajima Tamie

Abstract excerpt

Mutations of the p53 tumor-suppressor gene universally occur on exons 5-8 in human cancer. We analyzed these mutations in esophageal cancer tissue from 207 patients in China using 2 methods, single-strand conformation polymorphism (SSCP), one of the most frequently used methods, and the recently developed denaturing high-performance liquid chromatography (DHPLC), and compared their sensitivity and efficiency....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 15523690
DOI: 10.1002/ijc.20712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DHPLC is superior to SSCP in screening p53 mutations in esophageal cancer tissues.PMID 15523690Read ↗

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