Article
Detection of p53 gene mutations in aspiration biopsy specimens from suspected breast cancers by polymerase chain reaction-single strand conformation polymorphism analysis.
Japanese journal of cancer research : Gann - 1 Feb 1995
Sato T, Okazaki A, Okazaki M, Takahashi S, Hirata K
Abstract excerpt
Genomic DNA was extracted from aspiration biopsy specimens taken from 15 suspected cases of breast cancer, including 7 known cases of breast cancer, and the p53 gene was studied for evidence of mutation by using a polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis. In 5 of the 15 cases (33%), p53 gene mutation was identified and these tumors were subsequently histologically...
Topics
- Adult
- Aged
- Base Sequence
- Biopsy, Needle
- Breast Neoplasms
- DNA Mutational Analysis
- Female
- Genes, p53
- Humans
- Middle Aged
- Molecular Sequence Data