Article
The Transcriptional Modulator Interferon-Related Developmental Regulator 1 in Osteoblasts Suppresses Bone Formation and Promotes Bone Resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2016
Iezaki Takashi, Onishi Yuki, Ozaki Kakeru, Fukasawa Kazuya, Takahata Yoshifumi, Nakamura Yukari, Fujikawa Koichi, Takarada Takeshi, Yoneda Yukio, Yamashita Yui, Shioi Go, Hinoi Eiichi
Abstract excerpt
Bone homeostasis is maintained by the synergistic actions of bone-resorbing osteoclasts and bone-forming osteoblasts. Although interferon-related developmental regulator 1 (Ifrd1) has been identified as a transcriptional coactivator/repressor in various cells, little attention has been paid to its role in osteoblastogenesis and bone homeostasis thus far. Here, we show that Ifrd1 is a critical mediator of both the...
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