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HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice

1 Feb 2004

Abstract excerpt

Hepatocellular carcinoma (HCC) affects males in a significantly higher proportion than females and is one of the human cancers etiologically related to viral factors. Many studies provide strong evidence of the direct role that hepatitis B virus (HBV) plays in hepatic carcinogenesis, but the functions of HBV surface antigen (HBsAg) and X protein (HBx) in hepatocarcinogenesis through direct or indirect mechanisms...

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PMID: 14767984
DOI: 10.1002/hep.20076

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