Article
Hepatitis B x antigen and p53 in the development of hepatocellular carcinoma.
Journal of hepato-biliary-pancreatic surgery - 1 Jan 1998
Feitelson M A
Abstract excerpt
Hepatitis B virus (HBV) is one of the major etiological agents responsible for the appearance of chronic liver diseases, including hepatocellular carcinoma (HCC). There is increasing evidence that the HBV excoded x antigen (HBxAg) is involved in one or more steps that contribute to multistep hepatocarcinogenesis. Recent work has now defined one of these steps as the physical binding and functional inactivation of...
Topics
- Animals
- Carcinoma, Hepatocellular
- Hepatitis B
- Hepatitis B Antigens
- Hepatitis B virus
- Humans
- Liver Neoplasms
- Mutation
- Trans-Activators
- Tumor Suppressor Protein p53
