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Article

Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression.

European journal of cancer (Oxford, England : 1990) - 1 Oct 2014

Li Chi Han, Xu Feiyue, Chow Sheungching, Feng Lu, Yin Deling, Ng Tzi Bun, Chen Yangchao

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and chronic hepatitis B virus (HBV) infection is the major risk factor of HCC. The virus encodes HBV X (HBx) protein that plays a critical role in the development of HCC. Studies have revealed numerous HBx-altered genes and signalling pathways that heavily contribute to tumourigenesis of non-tumour hepatocytes. However, the role of HBx in...

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Identifiers

PMID: 25087183
DOI: 10.1016/j.ejca.2014.07.008

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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