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Article

HGF/c-Met related activation of β-catenin in hepatoblastoma.

Journal of experimental & clinical cancer research : CR - 12 Oct 2011

Purcell Rachel, Childs Margaret, Maibach Rudolf, Miles Carina, Turner Clinton, Zimmermann Arthur, Sullivan Michael

Abstract excerpt

BACKGROUND: Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis. While aberrant accumulation of the beta-catenin is a common event in HB, mutations or deletions in CTNNB1 (beta-catenin gene) do not always account for the high frequency of protein expression. In this study we have investigated alternative activation of beta-catenin by HGF/c-Met...

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Source

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Identifiers

PMID: 21992464
DOI: 10.1186/1756-9966-30-96
PMCID: PMC3207961

Genes

HGF
CTNNB1

Provenance

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