Article
c-Fos activated phospholipid synthesis is required for neurite elongation in differentiating PC12 cells.
Molecular biology of the cell - 1 Apr 2004
Gil Germán A, Bussolino Daniela F, Portal Maximiliano M, Alfonso Pecchio Adolfo, Renner Marianne L, Borioli Graciela A, Guido Mario E, Caputto Beatriz L
Abstract excerpt
We have previously shown that c-Fos activates phospholipid synthesis through a mechanism independent of its genomic AP-1 activity. Herein, using PC12 cells induced to differentiate by nerve growth factor, the genomic effect of c-Fos in initiating neurite outgrowth is shown as distinct from its nongenomic effect of activating phospholipid synthesis and sustaining neurite elongation. Blocking c-Fos expression...
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