Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Growth of peripheral and central nervous system tumors is supported by cytoplasmic c-Fos in humans and mice.

PloS one - 4 Mar 2010

Silvestre David C, Gil Germán A, Tomasini Nicolás, Bussolino Daniela F, Caputto Beatriz L

Abstract excerpt

BACKGROUND: We have previously shown that the transcription factor c-Fos is also capable of associating to endoplasmic reticulum membranes (ER) and activating phospholipid synthesis. Herein we examined phospholipid synthesis status in brain tumors from human patients and from NPcis mice, an animal model of the human disease Neurofibromatosis Type 1 (NF1). PRINCIPAL FINDINGS: In human samples, c-Fos expression was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Cell Proliferation
Share to Central Nervous System Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Endoplasmic Reticulum

Share to Neurofibromatosis 1

Share to Phosphorylation

Share to Proto-Oncogene Proteins c-fos

Source

Open in PubMed Open full text

Identifiers

PMID: 20209053
DOI: 10.1371/journal.pone.0009544
PMCID: PMC2832012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Growth of peripheral and central nervous system tumors is supported by cytoplasmic c-Fos in humans and mice.PMID 20209053Read ↗

c-Fos activated phospholipid synthesis is required for neurite elongation in differentiating PC12 cells.Semantic proximity Read ↗

Integrated Proteomics Identified Novel Activation of Dynein IC2-GR-COX-1 Signaling in Neurofibromatosis Type I (NF1) Disease Model CellsSemantic proximity Read ↗

The transcription factor Fos: a Janus-type regulator in health and disease.Semantic proximity Read ↗

Restored plasticity in a mouse model of neurofibromatosis type 1 via inhibition of hyperactive ERK and CREBSemantic proximity Read ↗

The proto-oncoprotein c-Fos negatively regulates hepatocellular tumorigenesis.Semantic proximity Read ↗

The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.Semantic proximity Read ↗

c-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cellsSemantic proximity Read ↗

c-Fos proto-oncoprotein is degraded by the proteasome independently of its own ubiquitinylation in vivo.Semantic proximity Read ↗

Eliminating c-fos as a candidate gene for early-onset familial Alzheimer's disease.Semantic proximity Read ↗

Degradation of cellular and viral Fos proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.