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Article

Mutations in ammonia transporter RhBG that impair NH3/NH4 + transport in patients with chronic kidney disease.

The Journal of physiology - 1 Mar 2026

Zhou He, Abdulnour-Nakhoul Solange, Hamm L Lee, Nakhoul Nazih L

Abstract excerpt

Chronic kidney disease (CKD) imposes a substantial health burden globally, with emerging evidence pointing to the significance of metabolic acidosis and low urinary NH4 + excretion resulting in poor CKD outcomes. The present study aims to identify in CKD patients, loss of function mutations in RhBG, one of the NH3/NH4 + transporters in the collecting duct, and to show that NH3/NH4 + transport is impaired by these...

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Identifiers

PMID: 41674104
DOI: 10.1113/JP288958
PMCID: PMC12953007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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