Article
Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1.
The EMBO journal - 25 Feb 2004
den Elzen Nicole R, O'Connell Matthew J
Abstract excerpt
The G2 DNA damage checkpoint delays mitotic entry via the upregulation of Wee1 kinase and the downregulation of Cdc25 phosphatase by Chk1 kinase, and resultant inhibitory phosphorylation of Cdc2. While checkpoint activation is well understood, little is known about how the checkpoint is switched off to allow cell cycle re-entry. To identify proteins required for checkpoint release, we screened for genes in...
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