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Article

The effect of disease-associated mutations on the folding pathway of human prion protein.

The Journal of biological chemistry - 23 Apr 2004

Apetri Adrian C, Surewicz Krystyna, Surewicz Witold K

Abstract excerpt

Propagation of transmissible spongiform encephalopathies is believed to involve the conversion of cellular prion protein, PrP(C), into a misfolded oligomeric form, PrP(Sc). An important step toward understanding the mechanism of this conversion is to elucidate the folding pathway(s) of the prion protein. We reported recently (Apetri, A. C., and Surewicz, W. K. (2002) J. Biol. Chem. 277, 44589-44592) that the...

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PMID: 14761942
DOI: 10.1074/jbc.M313581200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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