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Article

Early structural features in mammalian prion conformation conversion.

Prion - 1 Jan 2000

Legname Giuseppe

Abstract excerpt

The conversion to a disease-associated conformer (PrP(Sc)) of the cellular prion protein (PrP(C)) is the central event in prion diseases. Wild-type PrPC converts to PrP(Sc) in the sporadic forms of the disorders through an unknown mechanism. These forms account for up to 85% of all human (Hu) occurrences; the infectious types contribute for less than 1%, while genetic incidence of the disease is about 15%....

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Source

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Identifiers

PMID: 22453176
DOI: 10.4161/pri.6.1.18425
PMCID: PMC3338963

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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