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Article

Combining molecular dynamics simulations and experimental analyses in protein misfolding.

Advances in protein chemistry and structural biology - 1 Jan 2019

Wille Holger, Dorosh Lyudmyla, Amidian Sara, Schmitt-Ulms Gerold, Stepanova Maria

Abstract excerpt

The fold of a protein determines its function and its misfolding can result in loss-of-function defects. In addition, for certain proteins their misfolding can lead to gain-of-function toxicities resulting in protein misfolding diseases such as Alzheimer's, Parkinson's, or the prion diseases. In all of these diseases one or more proteins misfold and aggregate into disease-specific assemblies, often in the form of...

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PMID: 31928730
DOI: 10.1016/bs.apcsb.2019.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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