Article
Molecular dynamics as an approach to study prion protein misfolding and the effect of pathogenic mutations.
Topics in current chemistry - 1 Jan 2011
van der Kamp Marc W, Daggett Valerie
Abstract excerpt
Computer simulation of protein dynamics offers unique high-resolution information that complements experiment. Using experimentally derived structures of the natively folded prion protein (PrP), physically realistic dynamics and conformational changes can be simulated, including the initial steps of misfolding. By introducing mutations in silico, the effect of pathogenic mutations on PrP conformation and dynamics...
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