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Article

Structural determinants in prion protein folding and stability.

Journal of molecular biology - 11 Nov 2014

Benetti Federico, Biarnés Xevi, Attanasio Francesco, Giachin Gabriele, Rizzarelli Enrico, Legname Giuseppe

Abstract excerpt

Prions are responsible for a heterogeneous group of fatal neurodegenerative diseases, involving post-translational modifications of the cellular prion protein. Epidemiological studies on Creutzfeldt-Jakob disease, a prototype prion disorder, show a majority of cases being sporadic, while the remaining occurrences are either genetic or iatrogenic. The molecular mechanisms by which PrP(C) is converted into its...

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Identifiers

PMID: 25280897
DOI: 10.1016/j.jmb.2014.09.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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