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Article

An LQT mutant minK alters KvLQT1 trafficking.

American journal of physiology. Cell physiology - 1 Jun 2004

Krumerman Andrew, Gao Xiaohong, Bian Jin-Song, Melman Yonathan F, Kagan Anna, McDonald Thomas V

Abstract excerpt

Cardiac I(Ks), the slowly activated delayed-rectifier K(+) current, is produced by the protein complex composed of alpha- and beta-subunits: KvLQT1 and minK. Mutations of genes encoding KvLQT1 and minK are responsible for the hereditary long QT syndrome (loci LQT1 and LQT5, respectively). MinK-L51H fails to traffic to the cell surface, thereby failing to produce effective I(Ks). We examined the effects that...

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Identifiers

PMID: 14761891
DOI: 10.1152/ajpcell.00275.2003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

An LQT mutant minK alters KvLQT1 trafficking.PMID 14761891Read ↗

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome.Semantic proximity Read ↗

Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits.Semantic proximity Read ↗

MinK-KvLQT1 Fusion Proteins, Evidence for Multiple Stoichiometries of the Assembled I ChannelSemantic proximity Read ↗

Dominant-negative Effect of MinK-A8V Impairs I Ks and Disturbs Channel Structure: Importance of Clinical Surveillance in Mild LQTS Patients and Asymptomatic CarriersSemantic proximity Read ↗

Regulation of the Kv2.1 potassium channel by MinK and MiRP1.Semantic proximity Read ↗

Subunit composition of minK potassium channels.Semantic proximity Read ↗

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium currentSemantic proximity Read ↗

Dominant-Negative <i>KvLQT1</i> Mutations Underlie the LQT1 Form of Long QT SyndromeSemantic proximity Read ↗

Does hERG coassemble with a beta subunit? Evidence for roles of MinK and MiRP1.Semantic proximity Read ↗

Functional effects of mutations in KvLQT1 that cause long QT syndrome.Semantic proximity Read ↗

Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome.Semantic proximity Read ↗

Functional Interactions between KCNE1 C-Terminus and the KCNQ1 ChannelSemantic proximity Read ↗

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