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Article

Does hERG coassemble with a beta subunit? Evidence for roles of MinK and MiRP1.

Novartis Foundation symposium - 1 Jan 2005

Anantharam Arun, Abbott Geoffrey W

Abstract excerpt

The voltage-gated potassium channel formed by hERG pore-forming alpha subunits generates the IKr cardiac potassium current, and is considered essential for human ventricular repolarization. What is not certain is whether human IKr channels contain ancillary subunits in vivo. Two chief contenders for this role are MinK (encoded by KCNE1) and MiRP1 (KCNE2). MinK and MiRP1 are single transmembrane domain peptides...

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PMID: 16050264

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Does hERG coassemble with a beta subunit? Evidence for roles of MinK and MiRP1.PMID 16050264Read ↗

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac ArrhythmiaSemantic proximity Read ↗

Disease‐associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanismSemantic proximity Read ↗

Regulation of the Kv2.1 potassium channel by MinK and MiRP1.Semantic proximity Read ↗

Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6.Semantic proximity Read ↗

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome.Semantic proximity Read ↗

Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics.Semantic proximity Read ↗

A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs).Semantic proximity Read ↗

The voltage-gated channel accessory protein KCNE2: multiple ion channel partners, multiple ways to long QT syndrome.Semantic proximity Read ↗

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium currentSemantic proximity Read ↗

Subunit composition of minK potassium channels.Semantic proximity Read ↗

An LQT mutant minK alters KvLQT1 trafficking.Semantic proximity Read ↗

Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channelSemantic proximity Read ↗

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