Article
Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome.
The Journal of general physiology - 1 Dec 1998
Sesti F, Goldstein S A
Abstract excerpt
IKs channels are voltage dependent and K+ selective. They influence cardiac action potential duration through their contribution to myocyte repolarization. Assembled from minK and KvLQT1 subunits, IKs channels are notable for a heteromeric ion conduction pathway in which both subunit types contri...
Topics
- Animals
- CHO Cells
- Cricetinae
- Electric Conductivity
- Female
- Humans
- In Vitro Techniques
- Ion Channel Gating
- Ion Transport
- KCNQ Potassium Channels
- KCNQ1 Potassium Channel
- Kinetics
- Long QT Syndrome
- Membrane Potentials
- Mutation
- Oocytes
- Potassium Channels
- Potassium Channels, Voltage-Gated