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Article

Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome.

The Journal of general physiology - 1 Dec 1998

Sesti F, Goldstein S A

Abstract excerpt

IKs channels are voltage dependent and K+ selective. They influence cardiac action potential duration through their contribution to myocyte repolarization. Assembled from minK and KvLQT1 subunits, IKs channels are notable for a heteromeric ion conduction pathway in which both subunit types contribute to pore formation. This study was undertaken to assess the effects of minK on pore function. We first...

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Identifiers

PMID: 9834138
DOI: 10.1085/jgp.112.6.651
PMCID: PMC2229448

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Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome.PMID 9834138Read ↗

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Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits.Semantic proximity Read ↗

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome.Semantic proximity Read ↗

KCNQ1 p.D446E Variant as a Risk Allele for Arrhythmogenic Phenotypes: Electrophysiological Characterization Reveals a Complex Phenotype Affecting the Slow Delayed Rectifier Potassium Current (IKs) Voltage Dependence by Causing a Hyperpolarizing Shift and a Lack of Response to Protein Kinase A Activation.Semantic proximity Read ↗

Microscopic mechanisms for long QT syndrome type 1 revealed by single-channel analysis of I(Ks) with S3 domain mutations in KCNQ1.Semantic proximity Read ↗

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The conduction pore of a cardiac potassium channel.Semantic proximity Read ↗

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium currentSemantic proximity Read ↗

Subunit composition of minK potassium channels.Semantic proximity Read ↗

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