Article

Dominant-negative Effect of MinK-A8V Impairs I Ks and Disturbs Channel Structure: Importance of Clinical Surveillance in Mild LQTS Patients and Asymptomatic Carriers

2026-05-12

Abstract excerpt

<title>Abstract</title> Background. The slow delayed rectifier potassium current (I Ks ), formed by the assembly of the Kv7.1 ( <italic>KCNQ1</italic> ) and MinK ( <italic>KCNE1</italic> ) subunits, is essential for cardiac repolarization. Variants of either protein may disrupt this current and contribute to different types of Long QT Syndrome (LQTS), conditions that might lead to arrhythmi...

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Literature Corpus work: 3594e5cb-8119-526d-a55d-9a498b0388ef
DOI: 10.21203/rs.3.rs-9151984/v1

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