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Article

Functional effects of mutations in KvLQT1 that cause long QT syndrome.

Journal of cardiovascular electrophysiology - 1 Jun 1999

Wang Z, Tristani-Firouzi M, Xu Q, Lin M, Keating M T, Sanguinetti M C

Abstract excerpt

INTRODUCTION: The long QT syndrome (LQT) is caused by mutations in genes encoding ion channels that modulate the duration of ventricular action potentials. One of these genes, KVLQT1, encodes an alpha subunit that coassembles with another subunit, hminK, to form the cardiac slow delayed rectifier (I(Ks)) K+ channel. METHODS AND RESULTS: The functional effects of seven mutations in KVLQT1 were assessed using...

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Identifiers

PMID: 10376919
DOI: 10.1111/j.1540-8167.1999.tb00262.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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