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Article

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome.

Human molecular genetics - 1 Aug 1999

Bianchi L, Shen Z, Dennis A T, Priori S G, Napolitano C, Ronchetti E, Bryskin R, Schwartz P J, Brown A M

Abstract excerpt

Mutations in the minK gene KCNE1 have been linked to the LQT5 variant of human long QT syndrome. MinK assembles with KvLQT1 to produce the slow delayed rectifier K+ current IKs and may assemble with HERG to modulate the rapid delayed rectifier IKr. We used electrophysiological and immunocytochemical methods to compare the cellular phenotypes of wild-type minK and four LQT5 mutants co-expressed with KvLQT1 in...

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Identifiers

PMID: 10400998
DOI: 10.1093/hmg/8.8.1499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome.PMID 10400998Read ↗

An LQT mutant minK alters KvLQT1 trafficking.Semantic proximity Read ↗

Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits.Semantic proximity Read ↗

Does hERG coassemble with a beta subunit? Evidence for roles of MinK and MiRP1.Semantic proximity Read ↗

MinK-KvLQT1 Fusion Proteins, Evidence for Multiple Stoichiometries of the Assembled I ChannelSemantic proximity Read ↗

Regulation of the Kv2.1 potassium channel by MinK and MiRP1.Semantic proximity Read ↗

Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome.Semantic proximity Read ↗

Mutations in the hminK gene cause long QT syndrome and suppress IKs function.Semantic proximity Read ↗

Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channelSemantic proximity Read ↗

Disease‐associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanismSemantic proximity Read ↗

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium currentSemantic proximity Read ↗

Dominant-negative Effect of MinK-A8V Impairs I Ks and Disturbs Channel Structure: Importance of Clinical Surveillance in Mild LQTS Patients and Asymptomatic CarriersSemantic proximity Read ↗

N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome.Semantic proximity Read ↗

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