Article
Identification of paraoxonase 3 gene (PON3) missense mutations in a population of southern Italy.
Mutation research - 26 Feb 2004
Campo Salvatore, Sardo Adriana M, Campo Giuseppe M, Avenoso Angela, Castaldo Maria, D'Ascola Angela, Giunta Elena, Calatroni Alberto, Saitta Antonino
Abstract excerpt
PON gene family includes at least three members termed PON1, PON2 and PON3, and it is mapped on human chromosome 7q21-q22. PON1 and PON3 gene products are constituents of high density lipoprotein (HDL) and have many enzymatic properties and antioxidant activity. PONs are proposed to participate in the prevention of low density lipoprotein (LDL) oxidation. PON1 and PON2 genes have missense polymorphisms, but, to...
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