Article
Paraoxonase gene polymorphisms and haplotype analysis in a stroke population.
BMC medical genetics - 21 Mar 2006
Pasdar Alireza, Ross-Adams Helen, Cumming Alastair, Cheung John, Whalley Lawrence, St Clair David, MacLeod Mary-Joan
Abstract excerpt
BACKGROUND: Paraoxonase (PON) has anti-atherogenic activity due to its protective function against low density lipoprotein (LDL) oxidation. Alteration of enzyme activity due to polymorphisms in the PON genes may influence the development of atheroma and thus affect stroke risk. Three PON genes (PON1, PON2 and PON3) have been identifiedand mapped to chromosome 7. METHODS: We looked at the distribution of...
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