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Article

Reversal of liver fibrosis in aryl hydrocarbon receptor null mice by dietary vitamin A depletion.

Hepatology (Baltimore, Md.) - 1 Jan 2004

Andreola Fausto, Calvisi Diego F, Elizondo Guillermo, Jakowlew Sonia B, Mariano Jennifer, Gonzalez Frank J, De Luca Luigi M

Abstract excerpt

Aryl hydrocarbon receptor (AHR)-null mice display a liver fibrosis phenotype that is associated with a concomitant increase in liver retinoid concentration, tissue transglutaminase type II (TGaseII) activity, transforming growth factor beta (TGF beta) overexpression, and accumulation of collagen. To test the hypothesis that this phenotype might be triggered by the observed increase in liver retinoid content, we...

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Source

Identifiers

PMID: 14752834
DOI: 10.1002/hep.20004

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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