Article
Lesions of aryl-hydrocarbon receptor-deficient mice.
Veterinary pathology - 1 Nov 1997
Fernandez-Salguero P M, Ward J M, Sundberg J P, Gonzalez F J
Abstract excerpt
We have analyzed the possible role of the aryl-hydrocarbon receptor (AHR) in the aging process of mice using a homozygous null mouse (Ahr-/-) line as a model. We studied 52 male and female Ahr-/- mice aged from 6-13 months. Forty-six percent died or were ill by 13 months of age. Ahr-/- mice devel...
Topics
- Aging
- Animals
- Blood Vessels
- Cardiovascular Diseases
- Cardiovascular System
- Digestive System
- Disease Models, Animal
- Female
- Hair Follicle
- Homeostasis
- Hypertrophy
- Liver Diseases
- Male
- Mice
- Mice, Inbred C57BL
- Models, Genetic
- Myocardium
- Phenotype