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Article

Ah receptor represses acute-phase response gene expression without binding to its cognate response element.

Laboratory investigation; a journal of technical methods and pathology - 1 Jun 2009

Patel Rushang D, Murray Iain A, Flaveny Colin A, Kusnadi Ann, Perdew Gary H

Abstract excerpt

Repression of the nuclear factor-kappaB (NF-kappaB) pathway has been extensively researched because of its pivotal role in inflammation. We investigated the potential of the aryl hydrocarbon receptor (AHR) to suppress NF-kappaB regulated-gene expression, especially acute-phase genes, such as serum amyloid A (Saa). Using AHR mutants, it was determined that nuclear translocation and heterodimerization with...

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Source

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Identifiers

PMID: 19333233
DOI: 10.1038/labinvest.2009.24
PMCID: PMC2743259

Genes

AHR
EBP
RELA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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